Mathematical Modeling of Circadian Regulation on Glucose Metabolisms (4 Videos) | Dr. Hara
Week 3
Purpose
In this lecture, we will watch a presentation by the 2022 MORE (Mathematical sciences in Obesity Research Excellence) Lecture winner, Dr. Akane Hara on the mathematical modeling of circadian regulation on glucose metabolism.
The MORE Lecture was chosen after last year's course from literature according to the following criteria:
- Published on or after January 1, 2021 (either epub date or final publication date).
- Article should be an exemplar of:
- Rigor
- Data-driven conclusions
- Sound or especially creative use of advanced quantitative approaches to obesity and related sciences.
- Emphasis is on quality execution and communication of quantitative obesity science, with effect size and societal importance of results weighted less.
Meet the Guest Speaker
Dr. Hara is a mathematical biologist interested in the mechanisms of health problem development. She obtained her Ph.D. in March 2021 in Kyushu University, worked as a postdoctoral researcher (JSPS research fellow) at Hokkaido University for one year, and has been a visiting assistant professor at University of Toyama since April 2022.
Her research aim is to understand the pathogenesis of diseases that have not yet been elucidated and to discover the therapeutic methods from a new viewpoint using mathematical analysis. In this seminar, she will talk about her research on circadian clock regulation of glucose metabolism in mammals. She believes that the circadian rhythm has a significant impact on daily nutrient metabolism and is a key factor in lifestyle-related diseases such as obesity and diabetes. Based on simulation results using mathematical models, she would like to discuss the relationship between the meal timings and the circadian rhythm of nutrient metabolism.
Video Lecture
In the following video Dr. Hara lectures on why meals during resting time cause fat accumulation in mammals.
See the article here: Hara, A., & Satake, A. (2021). Why meals during resting time cause fat accumulation in mammals? Mathematical modeling of circadian regulation on glucose metabolism. Journal of Mathematical Biology, 83(3), 1-24.