How to Write an Original Research Article?

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Medical science involves discussions and the exchange of experiences and observations. These may occur through direct dialog among scientists, via paper presentations at conferences, or by means of scientific manuscripts in peer-reviewed journals. The publication of manuscripts is also used as a measure of the academic success of the researchers and scientists.

Therefore, it is important to know the way to write a manuscript. Most journals have a 'Guide for Author' that is available online. Prior to preparing your manuscript, one should download and carefully read the guidelines given under the 'Guide for Authors' of the journal where one intends to submit the manuscript. This guide contains detailed information about the interest and scope of the journal, specific manuscript types, and detailed instructions on formatting the manuscript.

A manuscript can be an original research article, review, case report, letter to the editor, editorial, or short communication. An original research article is a primary source of information and describes the study performed by researchers in a particular therapeutic area/disease.

According to the International Committee of Medical Journal Editors (ICMJE) guidelines, IMRAD (Introduction, Materials and Methods, Results, and Discussion) method should be followed for manuscript writing (original research article). Especially, if you're a student writing such things could be harder. In that case, seeking professional writing help would be the solution. They can help you with good research writings and you could edit them based on your needs.

Introduction: It introduces the readers to the theme of the research article, its background, and the researcher's perspective. It should clearly explain the reason and rationale of the study, and why anyone should care about the findings. Briefly, it should take the reader through the base of the study. An introduction should conclude with a clear statement about the primary and secondary (if any) hypothesis of the study.

Materials and Methods: This section is the most critical part of the manuscript. It should describe what exactly was done in the study in less than 1000 words. If the study involves human subjects or animals, approval from the Institutional Review Board and/or the Ethics Committee and informed consent of the human subjects must be obtained and mentioned in the manuscript. Besides these, study design, patient population, end-points, and treatment given must be described followed by statistical considerations.

Results: This section describes what was found in the study. The organization of the results should be parallel to the organization of the methods. The result section should start with the description of the population: how many subjects, how many protocol failures (if any), demographics of the patients, etc. This should be followed by the outcome of primary and secondary variables. The results of the study can be represented in the form of graphs or tables (with legends, abbreviations, and footnotes).

Discussion: This section explains the main findings of the study in a broader scientific or clinical context. Interpretation of the results is supported by the previous literature. Start with a brief description of the main findings to give the reader a quick overview. Subsequently, defend the model of the study and explain the rationale for the study methodology. Each part of the result section should be discussed in proper flow and sequence. The discussion should end with realistic conclusions, preferably in one or two sentences.

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