Course Syllabus

SPH-K 543: Cortical Control Of Human Movement

Many areas of the brain contribute to the control of movement.  Through lectures and discussions of primary literature, this course will examine our current understanding of the cortical and sub-cortical motor structures of the brain.  The student will learn the anatomy and physiology of these structures, their contributions to motor control, and the movement deficits that result from stroke or trauma to these regions.  We will cover the primary motor cortex, premotor cortex, supplementary motor area, cerebellum, and basal ganglia, and we will discuss posterior parietal cortex and the role of sensory information and neural networks in motor control.  We will also do a short writing assignment that students can submit to Neuro Forum, a publication of the Journal of Neurophysiology.

 

Competencies

 

The student will:

  • gain detailed knowledge of the behavioral and physiological functions of the motor structures in the human brain
  • become familiar with the deficits that result from disease or injury to motor structures of the brain
  • develop his or her ability to read, discuss, and present papers from the primary literature

Course instructor

Hannah Block, Ph.D.

E-mail:   hjblock@indiana.edu

Phone:   812-855-5390

Office:   SPH 112D

Associate Instructor

Najmeh Hoseini, P.T.

E-mail: nhoseini@indiana.edu

Office hours

By appointment

Meeting times

Tuesdays and Thursdays, 2:30-3:45pm

Classroom

SPH 012

 

Class schedule (subject to change):

 

Date

Topic

Required reading, Optional background reading

 

Tuesday, Aug. 26

Introduction

Kandel ch. 17-18

 

Thursday, Aug. 28

Principles of movement

Kandel ch. 33

 

Tuesday, Sept. 2

M1 lecture

Kandel ch. 38

 

Thursday, Sept. 4

Stroke—N. Hoseini

n/a

 

Tuesday, Sept. 9

TMS methods—N. Hoseini

Hallett 2007

 

Thursday, Sept. 11

Paper 1

Classen et al. 1998

 

Tuesday, Sept. 16

fMRI methods—Andy Jahn

n/a

 

Thursday, Sept. 18

Paper 2

Meier et al. 2008

 

Tuesday, Sept. 23

PMv lecture

Kandel ch. 38

 

Thursday, Sept. 25

Paper 3

Kakei et al. 2001

 

Tuesday, Sept. 30

Paper 4

Michael et al. 2014

 

Thursday, Oct. 1

PMd/SMA lecture

Kandel ch. 38

 

Tuesday, Oct. 7

Paper 5

Graziano et al. 2002

 

Thursday, Oct. 9

Paper 6

Entakli et al. 2013

 

Tuesday, Oct. 14

Review

n/a

 

Thursday, Oct. 16

MIDTERM

 

 

Tuesday, Oct. 21

Midterm postmortem & Cerebellum I

Kandel ch. 42

 

Thursday, Oct. 23

Cerebellum II

Kandel ch. 42

 

Tuesday, Oct. 28

Paper 7

Blakemore et al. 1998

 

Thursday, Oct. 30

Paper 8

Galea et al. 2011

 

Tuesday, Nov. 4

Basal Ganglia

Kandel ch. 43

 

Thursday, Nov. 6

Parkinsons disease—N. Hoseini

Kandel ch. 43

 

Tuesday, Nov. 11

Paper 9; MINI REVIEW TOPIC DUE

Smith et al. 2000

 

Thursday, Nov. 13

Parietal cortex

Grefkes et al. 2005

 

Tuesday, Nov. 18

SfN—no class

n/a

 

Thursday, Nov. 20

Paper 10

Reichenbach et al. 2014

 

Tuesday, Nov. 25

Thanksgiving—no class

n/a

 

Thursday, Nov. 27

Thanksgiving—no class

n/a

 

Tuesday, Dec. 2

Paper 11; MINI REVIEW DUE

Koch et al. 2008

 

Thursday, Dec. 4

Sensory control of movement

Bays & Wolpert 2007, Proske & Gandevia 2012

 

Tuesday, Dec. 9

MINI REVIEW DISCUSSION

n/a

 

Thursday, Dec. 11

Review

n/a

 

Dec. 15-19

FINAL EXAM

 

All required and optional readings will be provided in the appropriate module on the Canvas site for this course.  PowerPoint slides for each lecture will also be provided.

 

Grade

Grades will be assigned according to the following: 93-100% A;  90-93% A-;  87-90% B+;  83-87% B;  80-83% B-;  77-80% C+;  73-77% C;  70-73% C-;  67-70% D+;  63-67%D;  60-63% D-; <60% F.

  • 20% participation1
  • 15% presentations2
  • 45% exams (15% midterm, 30% final)
  • 20% mini review3 (15% your mini review, 5% peer review)

1 Even if not presenting the paper, each student is expected to participate (voluntarily or as called upon by the instructor) in the classes in which we discuss a paper.  Attendance and participation in the paper discussion classes are required and will count toward your participation grade.  The instructor will give each student (who is not presenting) a 0 or 1 each time.  A student who is absent, does not participate, or has clearly not read the paper will receive a 0. 

2 Each student will present 2 of the 11 papers and guide the discussion on those two days.  The presentation should include slides and should cover:

  1. background
  2. overview of method, results, and authors’ conclusions
  3. criticisms or weaknesses of the methods, results, or conclusions
  4. significance or importance of the paper

Detailed guidelines for the presentations are listed in the Resources folder of the course website.

3 Each student will write a mini review (2300 words max) of a current topic in motor control neuroscience.  Students will choose their own topics, subject to the instructor’s approval.  After the mini reviews are due (Dec. 2), students will be assigned each other’s work to review.  In class on Dec. 9, we will discuss and give feedback on each mini review.  Students are encouraged to revise their mini review according to the class’s suggestions and submit it to Neuro Forum, which is a publication of the Journal of Neurophysiology intended for graduate students and postdocs: http://www.the-aps.org/mm/Publications/Journals/JN/Neuro-Forum-Guidelines.html.  This is a great opportunity to get a peer-reviewed publication early in your graduate career, and a chance for the whole class to experience the review and publication process.

 

Course policies and procedures

1) Attendance will be taken at the instructor’s discretion. Various assignments will be given periodically in lecture. Make-ups will not be allowed for those assignments missed due to absence.

2) Make-up exams may only be scheduled if: an arrangement is made prior to the exam with the instructor’s permission; or a valid medical excuse is presented to the instructor within one week of the exam.

3) A grade of incomplete (I) will only be given in emergency circumstances (e.g., illness).

4) Academic and personal misconduct by students in this class are defined and dealt with according to the procedures in the Code of Student Ethics.

5) It is the policy of the School of Public Health to evaluate all courses taught in the School. Final student course evaluations will be conducted in a manner that maintains the integrity of the process and the anonymity of the evaluators. 

 

 

Course Summary:

Date Details Due